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Session ID: c43304fcfba4d75343fdac6c77594ccf

Search Type: drug

Started at: 2009-11-20 09:25:41

Finished at: 2009-11-20 09:28:16

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Field Result Source
Name
tyrosine External
Drugbank ID
Not Available Not Applicable
Description
Some of the tyrosine residues can be tagged with a phosphate group (phosphorylated) by protein kinases. (In its phosphorylated state, it is referred to as phosphotyrosine). Tyrosine phosphorylation is considered to be one of the key steps in signal transduction and regulation of enzymatic activity. Phosphotyrosine can be detected through specific antibodies. Tyrosine residues may also be modified by the addition of a sulfate group, a process known as tyrosine sulfation. Tyrosine sulfation is catalyzed by tyrosylprotein sulfotransferase (TPST). Like the phosphotyrosine antibodies mentioned above, antibodies have recently been described that specifically detect sulfotyrosine. Wikipedia
Thereby fumarate (also a metabolite of the citric acid cycle) and acetoacetate (3-ketobutyroate) are liberated. Acetoacetate is a ketone body, which is activated with succinyl-CoA, and thereafter it can be converted into acetyl-CoA which in turn can be oxidized by the citric acid cycle or be used for fatty acid synthesis. Wikipedia
Tyrosine (abbreviated as Tyr or Y) or 4-hydroxyphenylalanine, is one of the 20 amino acids that are used by cells to synthesize proteins. It is a non-essential amino acid with a polar side group. The word "tyrosine" is from the Greek tyros, meaning cheese, as it was first discovered in 1846 by German chemist Justus von Liebig in the protein casein from cheese. Wikipedia
Tyrosine is a precursor to neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine) but has little if any effect on mood. The effect on mood is more noticeable in humans subjected to stressful conditions (see below). Wikipedia
Chemical Kingdom
Organic BioSpider
Chemical Class
Amino Acids and Nitrogenous Compounds NuGO
Chemical Species
alpha-aminoacid Checkmol
aromatic compound Checkmol
carboxylic acid Checkmol
phenol or hydroxyhetarene Checkmol
primary aliphatic amine (alkylamine) Checkmol
primary amine Checkmol
Synonym
(+-)-tyrosine Pubchem
(+/-)-2-Amino-3-(4-hydroxyphenyl)propionic acid Pubchem
(-)-.alpha.-amino-p-hydroxyhydrocinnamic acid Pubchem
(.+-.)-tyrosine Pubchem
(2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid Pubchem
.alpha.-Amino-.beta.-(4-hydroxyphenyl)propionic acid Pubchem
2-AMINO-3-HYDROXYBUTYRIC ACID Pubchem
2-Amino-3-(4-hydroxyphenyl)-propanoic acid Pubchem
2-Amino-3-(p-hydroxyphenyl)propionic acid Pubchem
2-amino-3-(4-hydroxyphenyl)propanoic acid Pubchem
3-(4-Hydroxyphenyl)-DL-alanine Pubchem
3-(p-Hydroxyphenyl)alanine Pubchem
Benzenepropanoic acid, .alpha.-amino-4-hydroxy-, (S)- Pubchem
Beta-(p-hydroxyphenyl)alanine Pubchem
Beta-p-hydroxyphenylalanine Pubchem
D -3-[4-Hydroxyphenyl]alanine Pubchem
D-tyrosine Pubchem
DL-tyrosine Pubchem
L-2-Amino-3-p-hydroxyphenylpropanoic acid Pubchem
L-Phenylalanine, 4-hydroxy- Pubchem
L-p-tyrosine Pubchem
L-tryosine Pubchem
L-tyrosine Pubchem
L-tyrosine, free base Pubchem
L-tyrosine, u.s.p. Pubchem
Melanin Synthesized From Tyr Substrate Catalyzed By Tyrosinase For 6 Hrs Pubchem
P-tyrosine Pubchem
P1800_SIGMA Pubchem
Poly-l-tyrosine Pubchem
Propanoic acid, 2-amino-3-(4-hydroxyphenyl)-, (S)- Pubchem
TYR Pubchem
Tirosina Pubchem
Tyrosin Pubchem
Tyrosine, (l) Pubchem
Tyrosine, DL- Pubchem
Tyrosine, d- Pubchem
Tyrosine, l- Pubchem
UNII-A9BAT9B32M Pubchem
tyrosine (ACD/Name 4.0) NCI
Brand Mixture
20% Prosol (Alanine + Arginine + Dl-Methionine + Glutamic Acid + Glycine + Histidine + Isoleucine + L-Aspartic Acid + Leucine + Lysine (Lysine Acetate) + Phenylalanine + Proline + Serine + Threonine + Tryptophan + Tyrosine + Valine) DPD
Aminosyn 8.5% Injection with Electrolytes (Arginine + Glycine + Histidine + Isoleucine + L-Alanine + Leucine + Lysine (Lysine Acetate) + Magnesium Chloride + Methionine + Phenylalanine + Potassium Phosphate Dibasic + Proline + Serine + Sodium Chloride + Threonine + Tryptophan + Tyrosine + Valine) DPD
Nutrineal Pd4 (Alanine + Arginine + Calcium Chloride + Dl-Methionine + Glycine + Histidine + Isoleucine + Leucine + Lysine (Lysine Monohydrochloride) + Magnesium Chloride + Phenylalanine + Proline + Serine + Sodium Chloride + Sodium Lactate + Threonine + Tryptophan + Tyrosine + Valine) DPD
Travasol 10% Blend C Inj (Arginine + Glycine + Histidine + Isoleucine + L-Alanine + L-Lysine (L-Lysine Hydrochloride) + Leucine + Methionine + Phenylalanine + Proline + Serine + Threonine + Tryptophan + Tyrosine + Valine) DPD
Travasol Amino Acid Inj 5.5% (Alanine + Arginine + Glycine + Histidine + Isoleucine + L-Lysine (L-Lysine Hydrochloride) + Leucine + Magnesium Chloride + Methionine + Phenylalanine + Potassium Phosphate Dibasic + Proline + Sodium Acetate + Sodium Chloride + Threonine + Tryptophan + Tyrosine + Valine) DPD
Travasol Amino Acid Inj 8.5% (Alanine + Arginine + Glycine + Histidine + Isoleucine + L-Lysine (L-Lysine Hydrochloride) + Leucine + Magnesium Chloride + Methionine + Phenylalanine + Potassium Phosphate Dibasic + Proline + Sodium Acetate + Sodium Chloride + Threonine + Tryptophan + Tyrosine + Valine) DPD
Travasol Inj 10% (Alanine + Arginine + Glycine + Histidine + Isoleucine + L-Lysine (L-Lysine Hydrochloride) + Leucine + Magnesium Chloride + Methionine + Phenylalanine + Potassium Phosphate Dibasic + Proline + Sodium Acetate + Sodium Chloride + Threonine + Tryptophan + Tyrosine + Valine) DPD
Travasol Inj Without Electrolytes 10% (Arginine + Glycine + Histidine + Isoleucine + L-Alanine + L-Lysine Hydrochloride + Leucine + Methionine + Phenylalanine + Proline + Threonine + Tryptophan + Tyrosine + Valine) DPD
Travasol Inj Without Electrolytes 5.5% (Arginine + Glycine + Histidine + Isoleucine + L-Alanine + L-Lysine Hydrochloride + Leucine + Methionine + Phenylalanine + Proline + Threonine + Tryptophan + Tyrosine + Valine) DPD
Travasol Inj Without Electrolytes 8.5% (Arginine + Dl-Methionine + Glycine + Histidine + Isoleucine + L-Alanine + L-Lysine Hydrochloride + Leucine + Phenylalanine + Proline + Threonine + Tryptophan + Tyrosine + Valine) DPD
CAS
556-03-6 Kegg
InChI Identifier 
InChI=1/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10
H2,(H,12,13)
 World Wide Molecular Matrix
IUPAC
2-amino-3-(4-hydroxyphenyl)propanoic acid PubChem
Chemical Formula
C9H11NO3 PubChem
Chemical Structure
Chemical Structure Molconvert
Average Molecular Weight (g/mol)
181.188540 BioSpider
Monoisotopic Molecular Weight (g/mol)
181.073890 BioSpider
SMILES (Isomeric) 
O=C(O)C(N)Cc1ccc(O)cc1
 ChemSpider
SMILES (Canonical) 
C1=CC(=CC=C1CC(C(=O)O)N)O
 PubChem
Kegg Drug
Not Available Not Applicable
Kegg Compound
C01536 ChEBI
Pubchem Compound ID
1153 PubChem
Pubchem Substance ID
10387107 Pubchem
10387108 Pubchem
10387112 Pubchem
10527102 Pubchem
11448519 Pubchem
121178 Pubchem
124706 Pubchem
15171329 Pubchem
182188 Pubchem
207089 Pubchem
24318399 Pubchem
24439503 Pubchem
24848742 Pubchem
24898245 Pubchem
26759676 Pubchem
35233691 Pubchem
35233941 Pubchem
35234235 Pubchem
35234557 Pubchem
35234603 Pubchem
35234695 Pubchem
35234831 Pubchem
35234928 Pubchem
35234971 Pubchem
35235099 Pubchem
35235262 Pubchem
35235348 Pubchem
35235525 Pubchem
35235848 Pubchem
35235940 Pubchem
35236252 Pubchem
35236324 Pubchem
35236394 Pubchem
35236531 Pubchem
35236944 Pubchem
35236952 Pubchem
35237087 Pubchem
35237115 Pubchem
35237485 Pubchem
36518073 Pubchem
36518215 Pubchem
36518274 Pubchem
36518808 Pubchem
36518885 Pubchem
36519032 Pubchem
36522498 Pubchem
36522642 Pubchem
36526840 Pubchem
36526998 Pubchem
36528870 Pubchem
36529793 Pubchem
36535550 Pubchem
36535666 Pubchem
36535776 Pubchem
36536563 Pubchem
36536705 Pubchem
36537696 Pubchem
36541352 Pubchem
36541486 Pubchem
37905968 Pubchem
37909978 Pubchem
37915764 Pubchem
37916039 Pubchem
37916093 Pubchem
37916254 Pubchem
46504669 Pubchem
4697 Kegg
49748655 Pubchem
49857094 Pubchem
51075584 Pubchem
51075883 Pubchem
53800862 Pubchem
56270770 Pubchem
57320781 Pubchem
58023913 Pubchem
75320 Pubchem
76468137 Pubchem
7714267 Pubchem
81040560 Pubchem
81040627 Pubchem
8144543 Pubchem
8151006 Pubchem
81663374 Pubchem
83427262 Pubchem
85090236 Pubchem
85090237 Pubchem
85090239 Pubchem
85090240 Pubchem
85090253 Pubchem
OMIM ID
Not Available Not Applicable
ChEBI
18186 Chebi
BioCyc
ALPHA-METHYL-TYROSINE BioCyc
PharmGKB
PA451822 PharmGKB
HET ID
Not Available Not Applicable
DPD ID
00285528 DPD
00306436 DPD
00306444 DPD
00388742 DPD
00388750 DPD
00388769 DPD
00613339 DPD
00872296 DPD
02141450 DPD
02230810 DPD
Rxlist Link
Not Available Not Applicable
Wikipedia
tyrosine Wikipedia
Pdr Health Link
http://www.pdrhealth.com/drugs/altmed/altmed-mono.aspx?contentFileName=ame0418.xml&contentName=Tyrosine&contentId=574 PDRHealth
Melting Point
325 oC PhysProp
State
Solid BioSpider
MSDS Link
1258734434.pdf www.sciencelab.com
FDA Label
Not Available Not Applicable
Experimental Water Solubility
0.4 mg/mL at 20 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)] PhysProp
Predicted Water Solubility
7.67 mg/mL [Predicted by ALOGPS] Alogps
Experimental LogP
-2.04 [SANGSTER (1993)] PhysProp
Predicted LogP
-2.39 [Predicted by ALOGPS] Alogps
pKa
Not Available Not Applicable
SDF File
1258734375.sdf Pubchem
Mol File
1258734349.mol KEGG Compound
Pdb File
1258734438.pdb Molconvert
Mass Spec File
Not Available Not Applicable
Associated Disorder
Aromatic l-amino acid decarboxylase deficiency Metagene
Hartnup disease. behavioral disturbances, reversible Metagene
Hawkinsinuria Metagene
Liver disease, liver failure, unspecific Metagene
Phenylketonuria (pku) Metagene
Tyrosinemia I Metagene
Tyrosinemia II Metagene
Tyrosinemia III Metagene
Tyrosinemia, transient, of the newborn Metagene
Pathway
Not Available Not Applicable
Category
Not Available Not Applicable
ATC Code
H03BX01 WHO
H03BX02 WHO
AHFS Code
Not Available Not Applicable
Schedule
Not Available Not Applicable
Indication
Not Available Not Applicable
Pharmacology
Not Available Not Applicable
Mechanism Of Action
Not Available Not Applicable
Absorption
It decreases absorption of l-dopa Wikipedia
Tyrosine may decrease the absorption of other amino acids in high or chronic doses Wikipedia
Protein Binding
Not Available Not Applicable
Half Life
Not Available Not Applicable
Biotransformation
Not Available Not Applicable
Toxicity
Not Available Not Applicable
Dosage
Not Available Not Applicable
Patient Information
Not Available Not Applicable
Interactions
Not Available Not Applicable
Contraindications
Not Available Not Applicable
Targets
Not Available Not Applicable